Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine.
Identifieur interne : 000072 ( Main/Exploration ); précédent : 000071; suivant : 000073Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine.
Auteurs : Lenka Koklesova [Slovaquie] ; Alena Liskova [Slovaquie] ; Marek Samec [Slovaquie] ; Tawar Qaradakhi ; Anthony Zulli ; Karel Smejkal [République tchèque] ; Karol Kajo [Slovaquie] ; Jana Jakubikova [Slovaquie] ; Payam Behzadi [Iran] ; Martin Pec [Slovaquie] ; Pavol Zubor [Norvège, Slovaquie] ; Kamil Biringer [Slovaquie] ; Taeg Kyu Kwon [Corée du Sud] ; Dietrich Büsselberg [Qatar] ; Gustavo R. Sarria [Allemagne] ; Frank A. Giordano [Allemagne] ; Olga Golubnitschaja [Allemagne] ; Peter Kubatka [Slovaquie]Source :
- The EPMA journal [ 1878-5077 ] ; 2020.
Abstract
Severe durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified patient groups at the level of targeted primary (cancer development) and secondary (cancer progression and metastatic disease) prevention. Consequently, clinical implementation of knowledge accumulated in the area is still highly restricted. To stimulate coherent co-development of the dedicated plant bioactive compound investigation on one hand and comprehensive cancer preventive strategies on the other hand, the current paper highlights and deeply analyses relevant evidence available in the area. Key molecular mechanisms are presented to detail genoprotective and anticancer activities of plants and phytochemicals. Clinical implementation is discussed. Based on the presented evidence, advanced chemopreventive strategies in the context of 3P medicine are considered.
DOI: 10.1007/s13167-020-00210-5
PubMed: 32547652
PubMed Central: PMC7272522
Affiliations:
- Allemagne, Corée du Sud, Iran, Norvège, Qatar, République tchèque, Slovaquie
- District de Cologne, Rhénanie-du-Nord-Westphalie, Østlandet
- Bonn, Oslo
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of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Pec, Martin" sort="Pec, Martin" uniqKey="Pec M" first="Martin" last="Pec">Martin Pec</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin</wicri:regionArea><wicri:noRegion>03601 Martin</wicri:noRegion></affiliation></author><author><name sortKey="Zubor, Pavol" sort="Zubor, Pavol" uniqKey="Zubor P" first="Pavol" last="Zubor">Pavol Zubor</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gynecologic Oncology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Gynecologic Oncology, Norwegian Radium Hospital, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>OBGY Health & Care, Ltd., 01001 Zilina, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>OBGY Health & Care, Ltd., 01001 Zilina</wicri:regionArea><wicri:noRegion>01001 Zilina</wicri:noRegion></affiliation></author><author><name sortKey="Biringer, Kamil" sort="Biringer, Kamil" uniqKey="Biringer K" first="Kamil" last="Biringer">Kamil Biringer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin</wicri:regionArea><wicri:noRegion>036 01 Martin</wicri:noRegion></affiliation></author><author><name sortKey="Kwon, Taeg Kyu" sort="Kwon, Taeg Kyu" uniqKey="Kwon T" first="Taeg Kyu" last="Kwon">Taeg Kyu Kwon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology and School of Medicine, Keimyung University, Dalseo-Gu, Daegu, 42601 Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Immunology and School of Medicine, Keimyung University, Dalseo-Gu, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Busselberg, Dietrich" sort="Busselberg, Dietrich" uniqKey="Busselberg D" first="Dietrich" last="Büsselberg">Dietrich Büsselberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha, Qatar.</nlm:affiliation><country xml:lang="fr">Qatar</country><wicri:regionArea>Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Sarria, Gustavo R" sort="Sarria, Gustavo R" uniqKey="Sarria G" first="Gustavo R" last="Sarria">Gustavo R. Sarria</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Giordano, Frank A" sort="Giordano, Frank A" uniqKey="Giordano F" first="Frank A" last="Giordano">Frank A. Giordano</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Golubnitschaja, Olga" sort="Golubnitschaja, Olga" uniqKey="Golubnitschaja O" first="Olga" last="Golubnitschaja">Olga Golubnitschaja</name><affiliation wicri:level="3"><nlm:affiliation>Predictive, Preventive and Personalised (3P) Medicine, Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Predictive, Preventive and Personalised (3P) Medicine, Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Kubatka, Peter" sort="Kubatka, Peter" uniqKey="Kubatka P" first="Peter" last="Kubatka">Peter Kubatka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin</wicri:regionArea><wicri:noRegion>03601 Martin</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32547652</idno><idno type="pmid">32547652</idno><idno type="doi">10.1007/s13167-020-00210-5</idno><idno type="pmc">PMC7272522</idno><idno type="wicri:Area/Main/Corpus">000043</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000043</idno><idno type="wicri:Area/Main/Curation">000043</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000043</idno><idno type="wicri:Area/Main/Exploration">000043</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine.</title><author><name sortKey="Koklesova, Lenka" sort="Koklesova, Lenka" uniqKey="Koklesova L" first="Lenka" last="Koklesova">Lenka Koklesova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin</wicri:regionArea><wicri:noRegion>036 01 Martin</wicri:noRegion></affiliation></author><author><name sortKey="Liskova, Alena" sort="Liskova, Alena" uniqKey="Liskova A" first="Alena" last="Liskova">Alena Liskova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin</wicri:regionArea><wicri:noRegion>036 01 Martin</wicri:noRegion></affiliation></author><author><name sortKey="Samec, Marek" sort="Samec, Marek" uniqKey="Samec M" first="Marek" last="Samec">Marek Samec</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin</wicri:regionArea><wicri:noRegion>036 01 Martin</wicri:noRegion></affiliation></author><author><name sortKey="Qaradakhi, Tawar" sort="Qaradakhi, Tawar" uniqKey="Qaradakhi T" first="Tawar" last="Qaradakhi">Tawar Qaradakhi</name><affiliation><nlm:affiliation>Institute for Health and Sport, Victoria University, Melbourne, VIC Australia.</nlm:affiliation><wicri:noCountry code="subField">VIC Australia</wicri:noCountry></affiliation></author><author><name sortKey="Zulli, Anthony" sort="Zulli, Anthony" uniqKey="Zulli A" first="Anthony" last="Zulli">Anthony Zulli</name><affiliation><nlm:affiliation>Institute for Health and Sport, Victoria University, Melbourne, VIC Australia.</nlm:affiliation><wicri:noCountry code="subField">VIC Australia</wicri:noCountry></affiliation></author><author><name sortKey="Smejkal, Karel" sort="Smejkal, Karel" uniqKey="Smejkal K" first="Karel" last="Smejkal">Karel Smejkal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, 612 42 Brno, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, 612 42 Brno</wicri:regionArea><wicri:noRegion>612 42 Brno</wicri:noRegion></affiliation></author><author><name sortKey="Kajo, Karol" sort="Kajo, Karol" uniqKey="Kajo K" first="Karol" last="Kajo">Karol Kajo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, St. Elisabeth Oncology Institute, 812 50 Bratislava, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Department of Pathology, St. Elisabeth Oncology Institute, 812 50 Bratislava</wicri:regionArea><wicri:noRegion>812 50 Bratislava</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Biomedical Research Center, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Biomedical Research Center, Slovak Academy of Sciences, 845 05 Bratislava</wicri:regionArea><wicri:noRegion>845 05 Bratislava</wicri:noRegion></affiliation></author><author><name sortKey="Jakubikova, Jana" sort="Jakubikova, Jana" uniqKey="Jakubikova J" first="Jana" last="Jakubikova">Jana Jakubikova</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Research Center SAS, Cancer Research Institute, Bratislava, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Biomedical Research Center SAS, Cancer Research Institute, Bratislava</wicri:regionArea><wicri:noRegion>Bratislava</wicri:noRegion></affiliation></author><author><name sortKey="Behzadi, Payam" sort="Behzadi, Payam" uniqKey="Behzadi P" first="Payam" last="Behzadi">Payam Behzadi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, College of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Microbiology, College of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Pec, Martin" sort="Pec, Martin" uniqKey="Pec M" first="Martin" last="Pec">Martin Pec</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin</wicri:regionArea><wicri:noRegion>03601 Martin</wicri:noRegion></affiliation></author><author><name sortKey="Zubor, Pavol" sort="Zubor, Pavol" uniqKey="Zubor P" first="Pavol" last="Zubor">Pavol Zubor</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gynecologic Oncology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Gynecologic Oncology, Norwegian Radium Hospital, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>OBGY Health & Care, Ltd., 01001 Zilina, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>OBGY Health & Care, Ltd., 01001 Zilina</wicri:regionArea><wicri:noRegion>01001 Zilina</wicri:noRegion></affiliation></author><author><name sortKey="Biringer, Kamil" sort="Biringer, Kamil" uniqKey="Biringer K" first="Kamil" last="Biringer">Kamil Biringer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin</wicri:regionArea><wicri:noRegion>036 01 Martin</wicri:noRegion></affiliation></author><author><name sortKey="Kwon, Taeg Kyu" sort="Kwon, Taeg Kyu" uniqKey="Kwon T" first="Taeg Kyu" last="Kwon">Taeg Kyu Kwon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology and School of Medicine, Keimyung University, Dalseo-Gu, Daegu, 42601 Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Immunology and School of Medicine, Keimyung University, Dalseo-Gu, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Busselberg, Dietrich" sort="Busselberg, Dietrich" uniqKey="Busselberg D" first="Dietrich" last="Büsselberg">Dietrich Büsselberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha, Qatar.</nlm:affiliation><country xml:lang="fr">Qatar</country><wicri:regionArea>Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Sarria, Gustavo R" sort="Sarria, Gustavo R" uniqKey="Sarria G" first="Gustavo R" last="Sarria">Gustavo R. Sarria</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Giordano, Frank A" sort="Giordano, Frank A" uniqKey="Giordano F" first="Frank A" last="Giordano">Frank A. Giordano</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Golubnitschaja, Olga" sort="Golubnitschaja, Olga" uniqKey="Golubnitschaja O" first="Olga" last="Golubnitschaja">Olga Golubnitschaja</name><affiliation wicri:level="3"><nlm:affiliation>Predictive, Preventive and Personalised (3P) Medicine, Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Predictive, Preventive and Personalised (3P) Medicine, Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Kubatka, Peter" sort="Kubatka, Peter" uniqKey="Kubatka P" first="Peter" last="Kubatka">Peter Kubatka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin</wicri:regionArea><wicri:noRegion>03601 Martin</wicri:noRegion></affiliation></author></analytic><series><title level="j">The EPMA journal</title><idno type="ISSN">1878-5077</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified patient groups at the level of targeted primary (cancer development) and secondary (cancer progression and metastatic disease) prevention. Consequently, clinical implementation of knowledge accumulated in the area is still highly restricted. To stimulate coherent co-development of the dedicated plant bioactive compound investigation on one hand and comprehensive cancer preventive strategies on the other hand, the current paper highlights and deeply analyses relevant evidence available in the area. Key molecular mechanisms are presented to detail genoprotective and anticancer activities of plants and phytochemicals. Clinical implementation is discussed. Based on the presented evidence, advanced chemopreventive strategies in the context of 3P medicine are considered.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32547652</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1878-5077</ISSN><JournalIssue CitedMedium="Print"><Volume>11</Volume><Issue>2</Issue><PubDate><Year>2020</Year><Month>Jun</Month></PubDate></JournalIssue><Title>The EPMA journal</Title><ISOAbbreviation>EPMA J</ISOAbbreviation></Journal><ArticleTitle>Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine.</ArticleTitle><Pagination><MedlinePgn>261-287</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s13167-020-00210-5</ELocationID><Abstract><AbstractText>Severe durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified patient groups at the level of targeted primary (cancer development) and secondary (cancer progression and metastatic disease) prevention. Consequently, clinical implementation of knowledge accumulated in the area is still highly restricted. To stimulate coherent co-development of the dedicated plant bioactive compound investigation on one hand and comprehensive cancer preventive strategies on the other hand, the current paper highlights and deeply analyses relevant evidence available in the area. Key molecular mechanisms are presented to detail genoprotective and anticancer activities of plants and phytochemicals. Clinical implementation is discussed. Based on the presented evidence, advanced chemopreventive strategies in the context of 3P medicine are considered.</AbstractText><CopyrightInformation>© The Author(s) 2020.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Koklesova</LastName><ForeName>Lenka</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.</Affiliation><Identifier Source="GRID">grid.7634.6</Identifier><Identifier Source="ISNI">0000000109409708</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liskova</LastName><ForeName>Alena</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.</Affiliation><Identifier Source="GRID">grid.7634.6</Identifier><Identifier Source="ISNI">0000000109409708</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Samec</LastName><ForeName>Marek</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.</Affiliation><Identifier Source="GRID">grid.7634.6</Identifier><Identifier Source="ISNI">0000000109409708</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qaradakhi</LastName><ForeName>Tawar</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute for Health and Sport, Victoria University, Melbourne, VIC Australia.</Affiliation><Identifier Source="GRID">grid.1019.9</Identifier><Identifier Source="ISNI">0000 0001 0396 9544</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zulli</LastName><ForeName>Anthony</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Health and Sport, Victoria University, Melbourne, VIC Australia.</Affiliation><Identifier Source="GRID">grid.1019.9</Identifier><Identifier Source="ISNI">0000 0001 0396 9544</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smejkal</LastName><ForeName>Karel</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, 612 42 Brno, Czech Republic.</Affiliation><Identifier Source="GRID">grid.10267.32</Identifier><Identifier Source="ISNI">0000 0001 2194 0956</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kajo</LastName><ForeName>Karol</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pathology, St. Elisabeth Oncology Institute, 812 50 Bratislava, Slovakia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biomedical Research Center, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia.</Affiliation><Identifier Source="GRID">grid.419303.c</Identifier><Identifier Source="ISNI">0000 0001 2180 9405</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jakubikova</LastName><ForeName>Jana</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Biomedical Research Center SAS, Cancer Research Institute, Bratislava, Slovakia.</Affiliation><Identifier Source="GRID">grid.420087.9</Identifier><Identifier Source="ISNI">0000 0001 2106 1943</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Behzadi</LastName><ForeName>Payam</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Microbiology, College of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.</Affiliation><Identifier Source="GRID">grid.411463.5</Identifier><Identifier Source="ISNI">0000 0001 0706 2472</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pec</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.</Affiliation><Identifier Source="GRID">grid.7634.6</Identifier><Identifier Source="ISNI">0000000109409708</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zubor</LastName><ForeName>Pavol</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Gynecologic Oncology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.</Affiliation><Identifier Source="GRID">grid.55325.34</Identifier><Identifier Source="ISNI">0000 0004 0389 8485</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>OBGY Health & Care, Ltd., 01001 Zilina, Slovakia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Biringer</LastName><ForeName>Kamil</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.</Affiliation><Identifier Source="GRID">grid.7634.6</Identifier><Identifier Source="ISNI">0000000109409708</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kwon</LastName><ForeName>Taeg Kyu</ForeName><Initials>TK</Initials><AffiliationInfo><Affiliation>Department of Immunology and School of Medicine, Keimyung University, Dalseo-Gu, Daegu, 42601 Korea.</Affiliation><Identifier Source="GRID">grid.412091.f</Identifier><Identifier Source="ISNI">0000 0001 0669 3109</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Büsselberg</LastName><ForeName>Dietrich</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha, Qatar.</Affiliation><Identifier Source="GRID">grid.418818.c</Identifier><Identifier Source="ISNI">0000 0001 0516 2170</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sarria</LastName><ForeName>Gustavo R</ForeName><Initials>GR</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.</Affiliation><Identifier Source="GRID">grid.10388.32</Identifier><Identifier Source="ISNI">0000 0001 2240 3300</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giordano</LastName><ForeName>Frank A</ForeName><Initials>FA</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.</Affiliation><Identifier Source="GRID">grid.10388.32</Identifier><Identifier Source="ISNI">0000 0001 2240 3300</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Golubnitschaja</LastName><ForeName>Olga</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Predictive, Preventive and Personalised (3P) Medicine, Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.</Affiliation><Identifier Source="GRID">grid.10388.32</Identifier><Identifier Source="ISNI">0000 0001 2240 3300</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kubatka</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.</Affiliation><Identifier Source="GRID">grid.7634.6</Identifier><Identifier Source="ISNI">0000000109409708</Identifier></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>EPMA J</MedlineTA><NlmUniqueID>101517307</NlmUniqueID><ISSNLinking>1878-5077</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anti-inflammatory</Keyword><Keyword MajorTopicYN="N">Antibacterial</Keyword><Keyword MajorTopicYN="N">Anticancer</Keyword><Keyword MajorTopicYN="N">Antifungal</Keyword><Keyword MajorTopicYN="N">Antimutagenic effects</Keyword><Keyword MajorTopicYN="N">Antioxidant</Keyword><Keyword MajorTopicYN="N">Beneficiary effects</Keyword><Keyword MajorTopicYN="N">Biomarkers</Keyword><Keyword MajorTopicYN="N">Breast cancer</Keyword><Keyword MajorTopicYN="N">Chemoprevention</Keyword><Keyword MajorTopicYN="N">Colon cancer</Keyword><Keyword MajorTopicYN="N">Detoxification</Keyword><Keyword MajorTopicYN="N">Diet</Keyword><Keyword MajorTopicYN="N">Exogenous and endogenous agents</Keyword><Keyword MajorTopicYN="N">Genomic instability</Keyword><Keyword MajorTopicYN="N">Genoprotection</Keyword><Keyword MajorTopicYN="N">Genotoxicity</Keyword><Keyword MajorTopicYN="N">Glutaredoxins</Keyword><Keyword MajorTopicYN="N">Glutathione</Keyword><Keyword MajorTopicYN="N">Hydrogen peroxide</Keyword><Keyword MajorTopicYN="N">Nanoparticles</Keyword><Keyword MajorTopicYN="N">Nanotechnology</Keyword><Keyword MajorTopicYN="N">Oncology</Keyword><Keyword MajorTopicYN="N">Oxidative stress</Keyword><Keyword MajorTopicYN="N">Phytochemicals</Keyword><Keyword MajorTopicYN="N">Plant natural substances</Keyword><Keyword MajorTopicYN="N">Prebiotic</Keyword><Keyword MajorTopicYN="N">Preclinical and clinical study</Keyword><Keyword MajorTopicYN="N">Predictive Preventive Personalised Medicine (3PM, PPPM)</Keyword><Keyword MajorTopicYN="N">Probiotic</Keyword><Keyword MajorTopicYN="N">ROS</Keyword><Keyword MajorTopicYN="N">Scavanger</Keyword><Keyword MajorTopicYN="N">Superoxide dismutase</Keyword><Keyword MajorTopicYN="N">Therapeutic potential</Keyword><Keyword MajorTopicYN="N">Thioredoxin</Keyword><Keyword MajorTopicYN="N">Tumour</Keyword></KeywordList><CoiStatement>Conflict of interestThe authors declare that they have no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>05</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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IdType="pubmed">31387226</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Corée du Sud</li><li>Iran</li><li>Norvège</li><li>Qatar</li><li>République tchèque</li><li>Slovaquie</li></country><region><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li><li>Østlandet</li></region><settlement><li>Bonn</li><li>Oslo</li></settlement></list><tree><noCountry><name sortKey="Qaradakhi, Tawar" sort="Qaradakhi, Tawar" uniqKey="Qaradakhi T" first="Tawar" last="Qaradakhi">Tawar Qaradakhi</name><name sortKey="Zulli, Anthony" sort="Zulli, Anthony" uniqKey="Zulli A" first="Anthony" last="Zulli">Anthony Zulli</name></noCountry><country name="Slovaquie"><noRegion><name sortKey="Koklesova, Lenka" sort="Koklesova, Lenka" uniqKey="Koklesova L" first="Lenka" last="Koklesova">Lenka Koklesova</name></noRegion><name sortKey="Biringer, Kamil" sort="Biringer, Kamil" uniqKey="Biringer K" first="Kamil" last="Biringer">Kamil Biringer</name><name sortKey="Jakubikova, Jana" sort="Jakubikova, Jana" uniqKey="Jakubikova J" first="Jana" last="Jakubikova">Jana Jakubikova</name><name sortKey="Kajo, Karol" sort="Kajo, Karol" uniqKey="Kajo K" first="Karol" last="Kajo">Karol Kajo</name><name sortKey="Kajo, Karol" sort="Kajo, Karol" uniqKey="Kajo K" first="Karol" last="Kajo">Karol Kajo</name><name sortKey="Kubatka, Peter" sort="Kubatka, Peter" uniqKey="Kubatka P" first="Peter" last="Kubatka">Peter Kubatka</name><name sortKey="Liskova, Alena" sort="Liskova, Alena" uniqKey="Liskova A" first="Alena" last="Liskova">Alena Liskova</name><name sortKey="Pec, Martin" sort="Pec, Martin" uniqKey="Pec M" first="Martin" last="Pec">Martin Pec</name><name sortKey="Samec, Marek" sort="Samec, Marek" uniqKey="Samec M" first="Marek" last="Samec">Marek Samec</name><name sortKey="Zubor, Pavol" sort="Zubor, Pavol" uniqKey="Zubor P" first="Pavol" last="Zubor">Pavol Zubor</name></country><country name="République tchèque"><noRegion><name sortKey="Smejkal, Karel" sort="Smejkal, Karel" uniqKey="Smejkal K" first="Karel" last="Smejkal">Karel Smejkal</name></noRegion></country><country name="Iran"><noRegion><name sortKey="Behzadi, Payam" sort="Behzadi, Payam" uniqKey="Behzadi P" first="Payam" last="Behzadi">Payam Behzadi</name></noRegion></country><country name="Norvège"><region name="Østlandet"><name sortKey="Zubor, Pavol" sort="Zubor, Pavol" uniqKey="Zubor P" first="Pavol" last="Zubor">Pavol Zubor</name></region></country><country name="Corée du Sud"><noRegion><name sortKey="Kwon, Taeg Kyu" sort="Kwon, Taeg Kyu" uniqKey="Kwon T" first="Taeg Kyu" last="Kwon">Taeg Kyu Kwon</name></noRegion></country><country name="Qatar"><noRegion><name sortKey="Busselberg, Dietrich" sort="Busselberg, Dietrich" uniqKey="Busselberg D" first="Dietrich" last="Büsselberg">Dietrich Büsselberg</name></noRegion></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Sarria, Gustavo R" sort="Sarria, Gustavo R" uniqKey="Sarria G" first="Gustavo R" last="Sarria">Gustavo R. Sarria</name></region><name sortKey="Giordano, Frank A" sort="Giordano, Frank A" uniqKey="Giordano F" first="Frank A" last="Giordano">Frank A. Giordano</name><name sortKey="Golubnitschaja, Olga" sort="Golubnitschaja, Olga" uniqKey="Golubnitschaja O" first="Olga" last="Golubnitschaja">Olga Golubnitschaja</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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